The Effect of Aqueous Extract of Inocutis levis on Liver Histopathology and Hypertriglyceridemia in High Sucrose-fed Wistar Rats

Background: Diets rich in simple carbohydrates can induce obesity and metabolic syndrome. Objectives: In this study we investigated the effect of aqueous extract of Inocutis levis on the levels of serum lipids and liver tissue in high sucrose fed (HSF) rats. Methods: Thirty two male wistar rats were divided into 4 groups: 1- control, 2- a group that were fed with high sucrose solution for 12 weeks and 3&4- groups were intraperitoneally treated with doses of 50 and 150 mg/kg body weight aqueous extract I. levis for two weeks following high sucrose drinking. After 12 weeks serum lipids, liver enzymes and liver tissue were evaluated.  Liver tissue was stained with hematoxylin & eosin. Results: The results showed that HSF in rats increased triglyceride and liver enzymes and induced low grade inflammation in liver tissue compared to control group (P<0.001). In HSF rats treated with aqueous extract of I. levis, the levels of triglyceride were reduced in blood serum, and liver enzymes levels as AST were also lowered (P<0.001) (P<0.01). Moreover, aqueous extract of I. levis decreased leukocyte infiltration in liver tissue. Conclusion: On the Base of these results, I. levis may have the potential to control hypertriglyceridemia, and may reduce inflammation in liver tissue.